Spitfire
Spitfire V 316.jpg
Polish Spitfire VB from 303 (Polish) Squadron flown by S/Ldr Zumbach.
Role Fighter
Manufacturer Supermarine
Designer R. J. Mitchell
First flight 5 March 1936
Introduction 1938
Retired 1955, RAF
Primary user Royal Air Force
Produced 1938–1948
Number built 20,351
Variants Seafire
Spiteful
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Sensitivity % (TP/(TP+FN) Specificity %
Single nucleotide variants 99.65% (412,456/413,893) >99.99%
Insertions, deletions and indels by sequence analysis
1-10 bps 96.94% (17,070/17,608) >99.99%
11-50 bps 99.07% (957/966) >99.99%
Copy number variants (exon level dels/dups)
Clinical samples (small CNVs, n=52)
1 exon level deletion 92.3% (24/26) NA
2 exons level deletion/duplication 100.0% (11/11) NA
3-7 exons level deletion/duplication 93.3% (14/15) NA
Microdeletion/-duplication sdrs (large CNVs, n=37))
Size range (0.1-47 Mb) 100% (37/37)
Simulated CNV detection
2 exons level deletion/duplication 90.98% (7,357/8,086) 99.96%
5 exons level deletion/duplication 98.63% (7,975/8,086) 99.98%
     
The performance presented above reached by WES with the following coverage metrics
     
Mean sequencing depth at exome level 174x
Nucleotides with >20x sequencing coverage (%) 99.4%
NORMAL SKINICHTHYOSISMANAGEMENT STRATEGIES
Important role in innate immunity; barrier against infectionHigh risk for bacterial infection and sepsisClose monitoring of vital signs
Blood cultures if temperature/hemodynamic instability, lethargy
Aggressive treatment of infections
Topical antibiotics to fissures
Reverse isolation
Maintenance of fluid-electrolyte balance; barrier against excessive lossesIncreased water loss; risk of dehydration and electrolyte imbalanceMonitor fluid balance by intake, urinary output, daily weights
Regular serum electrolytes with repletion
Humidified incubator
Nutrition Consult
Intravenous hydration
Barrier against chemical and mechanical assaultsRisk of systemic absorption of topicals; skin fragilityBland emollients only
Avoid silver sulfadiazine, lactic acid and salicylic acid preparations, antibacterial soaps
Minimal handling
Avoid conventional adhesives; use self-adherent wraps or gauze
Flexible and pliable to allow full range of motion of body partsRisk of restriction of lung movement; difficulty sucking/feeding; contractures; compartment syndromeRespiratory support
Nasogastric feeding
Liberal emollients, daily bathing and/or retinoids to thin scale
Monitor perfusion and compartment pressure
Orthopedic or plastic surgery consult in cases of contractures or constriction
Ophthalmology consult in cases of ectropion
Spitfire
Spitfire V 316.jpg
Polish Spitfire VB from 303 (Polish) Squadron flown by S/Ldr Zumbach.
Role Fighter
Manufacturer Supermarine
Designer R. J. Mitchell
First flight 5 March 1936
Introduction 1938
Retired 1955, RAF
Primary user Royal Air Force
Produced 1938–1948
Number built 20,351
Variants Seafire
Spiteful
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